{"id":9,"date":"2021-08-09T20:27:11","date_gmt":"2021-08-09T20:27:11","guid":{"rendered":"https:\/\/biodelya.com\/?page_id=9"},"modified":"2024-06-18T14:24:04","modified_gmt":"2024-06-18T14:24:04","slug":"home","status":"publish","type":"page","link":"https:\/\/biodelya.com\/index.php\/home\/","title":{"rendered":"Team"},"content":{"rendered":"\t\t
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Current Team Members<\/h1>\n

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Yann Chalopin (Ph.D., M.S., Eng.<\/strong><\/span>)<\/h3>

Yann Chalopin<\/strong><\/span>, Ph.D., is a CNRS \nresearch scientist at Ecole CentraleSupelec, where he leads a research \ngroup focused on the theoretical aspects of molecular physics physical biology of complex systems. His work aims to develop a fundamental \nunderstanding of the functional dynamics of macromolecular complexes, \nparticularly enzymes and proteins, by applying principles from condensed\n matter physics.<\/span><\/span>\nDr. Chalopin's academic journey began at Ecole Centrale Paris, \nwhere he obtained his M.S. in Solid State Physics in 2006 under the \nsupervision of Prof. J.J. Greffet. He continued his doctoral studies at \nthe same institution, earning a Ph.D. in 2009 with a dissertation on \nnanoscale energy transport and near-field optics.<\/span><\/span>\nFollowing his doctoral studies, Dr. Chalopin pursued postdoctoral \nresearch at the Massachusetts Institute of Technology (MIT) from 2009 to\n 2010, collaborating with Prof. Gang Chen's group. This experience \nbroadened his expertise in the field of energy transport at the \nnanoscale and laid the foundation for his current research interests.<\/span><\/span>\nDr. Chalopin's research group at Ecole CentraleSupelec employs a \nmultidisciplinary approach, integrating concepts from condensed matter \nphysics, biophysics, and computational biology. They develop theoretical\n models and computational tools to investigate the intricate mechanisms \ngoverning the structure, dynamics, and function of complex biological \nmacromolecules.<\/span><\/span>\nSpecific areas of focus include:<\/span>\n\nThrough his research, Dr. Chalopin aims to uncover fundamental \nprinciples governing the behavior of complex biological systems and \ncontribute to the development of novel strategies for understanding and \nengineering enzyme function, allosteric regulation, and protein-based \ntherapeutics.<\/span><\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Malcolm Buckle (Ph.D)<\/h3>

Malcolm Buckle<\/b> is currently a Director of Research in the CNRS in France\n and was director of a fundamental biology research laboratory (LBPA) at\n the Ecole Normale Sup\u00e9rieure Paris-Saclay from 2011 to the end of 2019.\n Following a PhD in Solid Phase Peptide Synthesis with Roger Epton at \nWolverhampton Polytechnic in the UK (1980), he held a series of \npost-doctoral positions in Canada, Italy and France and finally became a\n senior scientist at the CNRS working with Dr Henri Buc at the Pasteur \nInstitute Paris.  After moving to the ENS Cachan, in 2002 he directed a \ngroup working on the control and regulation of transcription. Although \nhis research interests have covered a fairly broad spectrum ranging from\n solid phase peptide synthesis through bioenergetics to the control of \ngene expression, he has always been struck by the necessity of \ndeveloping techniques that allow time-resolved analysis of dynamic \nsystems. This has led to the development and use of rapid high-energy UV\n lasers to follow the photo-reactivity of DNA involved in nucleoprotein \ncomplexes leading culminating in the PhAST (Photochemical Analysis of \nStructural Transitions) technique. Malcolm was an early user of emerging\n technologies based on Surface Plasmon Resonance (SPRi) and quickly \nrealised that these techniques were severely limited by problems \nassociated with the interface between a surface-based biosensor surface \n(a biochip) and macromolecules in solution. His group developed a unique\n surface chemistry with a wide range of applications ranging from \nbiosensor surfaces to nanoparticles with tremendous potential for use in\n diagnostic assays. Malcolm was recently involved in a maturation phase \nfor valorisation of this chemistry with the aim of creating a start-up \ncompany. Current research is focused on the dynamics of nucleoprotein \ncomplexes, specifically nucleosomes, and increasingly the role of \norder\/disorder transitions in proteins and their role in protein \nstructure\/function related to evolution and disease, again from a \ndynamic point of view.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Elouan Bethuel (Ph.D Candidate)<\/h3>

Elouan Bethuel <\/b>is a Ph.D. candidate in the research group led by \nDr. Yann Chalopin at Ecole CentraleSupelec. His research focuses on \ndeveloping computational methods for analyzing high-throughput \nsequencing data to map DNA chemical modifications and study epigenetic \nregulation.<\/span><\/span>\nElouan holds a double-discipline Bachelor's degree from Sorbonne \nUniversity, where he gained a strong foundation in bioinformatics, \ngenomics, and molecular dynamics. He further honed his skills in signal \nprocessing, machine learning, and programming during his Master's in \nBioinformatics at the University of Paris-Cit\u00e9.<\/span><\/span>\nPrior to his doctoral studies, Elouan completed a 2-year \nwork-study program at the UMR Epigenetics and Cell Fate laboratory under\n the supervision of Dr. Magali Hennion. During this apprenticeship, he \ndeveloped an automated pipeline enabling biologists to analyze \nhigh-throughput sequencing data for mapping DNA chemical modifications, \ndemonstrating his expertise in epigenomics and computational biology.<\/span><\/span>\nElouan's multidisciplinary background and experience in \nepigenetics, genomics, and bioinformatics make him a valuable asset to \nthe research group. His doctoral research aims to advance the \nunderstanding of epigenetic regulation by developing innovative \ncomputational approaches for analyzing and interpreting high-throughput \nsequencing data related to DNA chemical modifications.<\/span><\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Current Team Members Yann Chalopin (Ph.D., M.S., Eng.) Yann Chalopin, Ph.D., is a CNRS research scientist at Ecole CentraleSupelec, where he leads a research group focused on the theoretical aspects of molecular physics physical biology of complex systems. His work aims to develop a fundamental understanding of the functional dynamics of macromolecular complexes, particularly enzymes…
Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"yoast_head":"\nTeam - Physical Biology of Complex Systems Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biodelya.com\/index.php\/home\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Team - Physical Biology of Complex Systems Group\" \/>\n<meta property=\"og:description\" content=\"Current Team Members Yann Chalopin (Ph.D., M.S., Eng.) Yann Chalopin, Ph.D., is a CNRS research scientist at Ecole CentraleSupelec, where he leads a research group focused on the theoretical aspects of molecular physics physical biology of complex systems. 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